Resource Type

Journal Article 1276

Conference Videos 19

Year

2023 52

2022 59

2021 69

2020 61

2019 52

2018 55

2017 60

2016 63

2015 64

2014 74

2013 53

2012 46

2011 61

2010 73

2009 77

2008 78

2007 92

2006 31

2005 39

2004 35

open ︾

Keywords

function 15

COVID-19 10

numerical simulation 10

development strategy 9

optimization 8

the Qinba Mountain Area 8

different 7

parametric study 7

sustainable development 7

DX pile 6

experimental study 6

mechanism 6

gene expression 5

gene therapy 5

microstructure 5

project management 5

settlement 5

case study 4

conventional 4

open ︾

Search scope:

排序： Display mode:

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Strategic Study of CAE 2000, Volume 2, Issue 11,   Pages 1-11

Abstract:

In this paper, the study on family collection, gene mapping, gene identification and gene functiont (1; 3) (q44; p11) associated with nasopharyngeal cancer was found in 1975 at first, and human TDF geneIn 1998, GJB3, a human genetic neurological deafness gene, was identified using a novel strategy of “Gene Family-Candidate Disease Gene Cloning”，and the paper was published in Nature Geneticswas also cloned from gene function study.

Keywords： genetic disease     gene mapping and cloning     gene familiy-candidate disease gene cloning     genome wide scan     gene function study    

HTML PDF Collect

Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panelstudy

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 574-583 doi: 10.1007/s11684-021-0882-1

Abstract: The effect of air pollution on the lung function of adults with asthma remains unclear to date.This study followed 112 patients with asthma at 3-month intervals for 2 years.The participants were divided into three groups according to their lung function level at every visitA linear mixed-effect model was applied to predict the change in lung function with each unit changePatients with asthma react differently to air pollutants as evidenced by their lung function levels.

Keywords： lung function     asthma     air pollution     adult    

HTML PDF Collect

Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

Frontiers of Engineering Management 2016, Volume 3, Issue 1,   Pages 30-38 doi: 10.15302/J-FEM-2016008

Abstract: The authors performed genome-wide association study (GWAS) by 179 cases and 179 controls using the U.SThe authors observed that the gene frequencies of 34 single-nucleotide polymorphisms (SNPs) in threeThe results indicated that SNP rs6069499 within linked CBLN4 gene are strongly associated with accidentAccording to CBLN4 gene mainly involved in adrenal development and the regulation of secretion, the authors

Keywords： accident proneness     genome-wide association study (GWAS)     dopamine (DA)     ACTH     susceptibility gene     traffic    

HTML PDF Collect

A microarray study of altered gene expression during melanoblasts migration in normal pigmented White

Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 299-306 doi: 10.15302/J-FASE-2014040

Abstract: vertebrates, melanocytes in Silky Fowl can reach the ventral regions of the embryos owing to differences in geneIn this study, we used microarray profiling to identify differences in gene expression between WhiteThe candidate genes discovered in this study are beneficial to understand the molecular mechanism of

Keywords： Silky Fowl     White Leghorn     melanoblast migration     gene expression    

HTML PDF Collect

Design, synthesis, biological activity and density function theory study of pyrazole derivatives containing

Xiaoming Ding, Zhiwen Zhai, Luping Lv, Zhaohui Sun, Xinghai Liu

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 3,   Pages 379-386 doi: 10.1007/s11705-017-1634-2

Abstract: The structure-activity relationship of compounds and was also studied by density function theory

Keywords： pyrazole     1     3     4-thiadiazole     antifungal activity     herbicidal activity     density function theory    

HTML PDF Collect

Recent advances in fruit crop genomics

Qiang XU,Chaoyang LIU,Manosh Kumar BISWAS,Zhiyong PAN,Xiuxin DENG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 21-27 doi: 10.15302/J-FASE-2014002

Abstract: In recent years, dramatic progress has been made in the genomics of fruit crops. The publication of a dozen fruit crop genomes represents a milestone for both functional genomics and breeding programs in fruit crops. Rapid advances in high-throughput sequencing technology have revolutionized the manner and scale of genomics in fruit crops. Research on fruit crops is encompassing a wide range of biological questions which are unique and cannot be addressed in a model plant such as . This review summarizes recent achievements of research on the genome, transcriptome, proteome, miRNAs and epigenome of fruit crops.

Keywords： fruit crops     fruit biology     gene function     genomics    

HTML PDF Collect

Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 438-447 doi: 10.1007/s11684-020-0826-1

Abstract: Our study identified a profile of known heritable TAD genes in the Chinese STAD population and found

Keywords： sporadic thoracic aortic dissection     exome sequencing     gene COL3A1     case–control study     extracellular    

HTML PDF Collect

The genetics of Beh?et’s disease in a Chinese population

Shengping Hou, Aize Kijlstra, Peizeng Yang

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 354-359 doi: 10.1007/s11684-012-0234-2

Abstract: A large number of gene polymorphisms were studied including STAT4, IL23R, CD40, CCR1

Keywords： et’s disease     SNPs     immune gene     genetic study    

HTML PDF Collect

Study on Particle Size and Its Distribution Function of Standard Fire Smoke

Shu Xueming,Zheng Kui,Yuan Hongyong,Yao Bin

Strategic Study of CAE 2005, Volume 7, Issue 8,   Pages 51-55

Abstract: The particle size distribution function of smoke were studied by mathematic fitting methods, and the

Keywords： smoke     particle     size     distribution function    

HTML PDF Collect

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 230-233 doi: 10.1007/s11684-007-0045-z

Abstract: A nested case-control study ( = 738) was carried out.

Keywords： case-control     significant difference     reaction-restriction fragment     C825T polymorphism     evidence    

HTML PDF Collect

A Comprehensive Study of Gene Expression and Molecular Regulation Following Spinal Cord Injury

Kwok-Fai So

Engineering 2020, Volume 6, Issue 4,   Pages 389-390 doi: 10.1016/j.eng.2019.12.017

HTML PDF Collect

Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-controlstudy in Han Chinese people

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 90-95 doi: 10.1007/s11684-010-0021-x

Abstract: This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 geneWe conducted a population-based, case-control study enrolling 630 Han Chinese people in Hubei province

Keywords： cyclooxygenase-2 gene     single nucleotide polymorphisms     susceptibility     primary hepatocellular carcinoma    

HTML PDF Collect

Basic model study on efficiency evaluation in collaborative design work process

XIE Qiu, YANG Yu, LI Xiaoli, ZHAO Ningyu

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 3,   Pages 344-349 doi: 10.1007/s11465-007-0060-4

Abstract: built for centralized collaborative design work, includes an analytical frame, a process view model, a function

Keywords： function     system work     evaluation process     efficiency evaluation     design work    

HTML PDF Collect

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 621-628 doi: 10.1007/s11684-020-0738-0

Abstract: Multi-gene assays have emerged as crucial tools for risk stratification in early-stage breast cancer.This study aimed to evaluate the prognostic significance of the 21-gene recurrence score (RS) in Chinese

Keywords： early breast cancer     21-gene assay     recurrence score     prognosis    

HTML PDF Collect

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 4,   Pages 663-675 doi: 10.1007/s11705-017-1623-5

Abstract: Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases, as long as they can be delivered safely and effectively into cells. Dendrimers are appealing vectors for siRNA delivery by virtue of their well-defined molecular architecture and multivalent cooperativity. However, the clinical translation of RNA therapeutics mediated by dendrimer delivery is hampered by the lack of dendrimers that are of high quality to meet good manufacturing practice standard. In this context, we have developed small amphiphilic dendrimers that self-assemble into supramolecular structures, which mimic high-generation dendrimers synthesized with covalent construction, yet are easy to produce in large amount and superior quality. Indeed, the concept of supramolecular dendrimers has proved to be very promising, and has opened up a new avenue for dendrimer-mediated siRNA delivery. A series of self-assembling supramolecular dendrimers have consequently been established, some of them out-performing the currently available nonviral vectors in delivering siRNA to various cell types and , including human primary cells and stem cells. This short review presents a brief introduction to RNAi therapeutics, the obstacles to their delivery and the advantages of dendrimer delivery vectors as well as our bio-inspired structurally flexible dendrimers for siRNA delivery. We then highlight our efforts in creating self-assembling amphiphilic dendrimers to construct supramolecular dendrimer nanosystems for effective siRNA delivery as well as the related structural alterations to enhance delivery efficiency. The advent of self-assembling supramolecular dendrimer nanovectors holds great promise and heralds a new era of dendrimer-mediated delivery of RNA therapeutics in biomedical applications.

Keywords： gene therapy     RNAi therapeutics     dendrimer     nanovectors     gene silencing    

HTML PDF Collect

Title Author Date Type Operation

Study on Family Collection, Gene Mapping, Gene Identification and Gene Function of Human Genetic Diseases

Xia Jiahui

Journal Article

Lung function and air pollution exposure in adults with asthma in Beijing: a 2-year longitudinal panelstudy

Journal Article

Genetic Study Identifies CBLN4 as a Novel Susceptibility Gene for Accident Proneness

Shu-lin Zhang,Hui-qing Jin,Yang Song,Wan-sheng Yu,Liang-dan Sun

Journal Article

A microarray study of altered gene expression during melanoblasts migration in normal pigmented White

Yulin LI,Deping HAN,Junying LI,Dawn KOLTES,Xuemei DENG

Journal Article

Design, synthesis, biological activity and density function theory study of pyrazole derivatives containing

Xiaoming Ding, Zhiwen Zhai, Luping Lv, Zhaohui Sun, Xinghai Liu

Journal Article

Recent advances in fruit crop genomics

Qiang XU,Chaoyang LIU,Manosh Kumar BISWAS,Zhiyong PAN,Xiuxin DENG

Journal Article

Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

Journal Article

The genetics of Beh?et’s disease in a Chinese population

Shengping Hou, Aize Kijlstra, Peizeng Yang

Journal Article

Study on Particle Size and Its Distribution Function of Standard Fire Smoke

Shu Xueming,Zheng Kui,Yuan Hongyong,Yao Bin

Journal Article

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

Journal Article

A Comprehensive Study of Gene Expression and Molecular Regulation Following Spinal Cord Injury

Kwok-Fai So

Journal Article

Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-controlstudy in Han Chinese people

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

Journal Article

Basic model study on efficiency evaluation in collaborative design work process

XIE Qiu, YANG Yu, LI Xiaoli, ZHAO Ningyu

Journal Article

Prognostic value of the 21-gene recurrence score in ER-positive, HER2-negative, node-positive breastcancer was similar in node-negative diseases: a single-center study of 800 patients

Jiayi Wu, Weiqi Gao, Xiaosong Chen, Chunxiao Fei, Lin Lin, Weiguo Chen, Ou Huang, Siji Zhu, Jianrong He, Yafen Li, Li Zhu, Kunwei Shen

Journal Article

Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing

Yu Cao, Xiaoxuan Liu, Ling Peng

Journal Article